PHARMACEUTICAL PROCESSING | JANUARY/FEBRUARY 2015 31 n
ed the punches with the matte finish in a mix of
other punches that had chrome coating, chromium nitride coating, diamond like carbon coating and a specialty nickel based coating applied
to them. A comprehensive performance of each
coating was tested and evaluated.
All of the test tools were run at the same
time in the same tablet press turret. Tablets
were identified as to their compression station of origin by utilizing micro indentations in
the lower punch cup. Tablets were segregated
by punch station after the experiment so that
tablet defects could be attributed to a specific
punch coating or tablet configuration.
The matte finish yielded a reduction in
tablet defects that was a factor of two better
than any of the other coatings. This reduction
in defects allowed the customer to consider
minor tablet design changes and couple them
with the matte finish on the punch cups to
resolve a significant manufacturing problem.
Need for More Research
More research is needed to better predict in
which situations this punch cup finish should n
be used, but it is a simple technology innova-
tion that is worth additional investigation.
Clearly, this is a situation where research and
experimentation with existing treatments and
processes can help resolve some of the tableting industry’s most pervasive problems.
Additional research into the utility of
the matte finish will be investigated at the
Natoli Institute for Industrial Pharmacy
Research and Development. Natoli recently
opened the Institute in partnership with
the Arnold and Marie Schwartz College
of Pharmacy and Health Sciences on the
Brooklyn campus of Long Island University
(LIU). The Institute is dedicated to
researching tableting issues that manufacturers face every day.
Supporting one of the few industrial pharmacy programs in North America, the Institute is
committed to advancing knowledge in the field
of pharmaceutical solid oral dosage formulation
and engineering, and features traditional solid
dosage formulation equipment, as well as the
technology to measure the physical and chemical properties of tablets.
Natoli established the Institute to advance
pharmaceutical compression science and
to provide research opportunities to undergraduate and graduate students to enable
them to find innovative solutions to formulation problems through research and implementation.
Tablet manufacturers can submit projects
for consideration by the Institute. This provides industrial pharmacy students with real-world experience while helping manufacturers to have their tableting issues investigated
in a laboratory setting.
Although the Institute has only been open
for a few months, several projects have been
completed that have yielded solutions. The
use of matte finish is one solution that may
provide results to tablet manufacturers experiencing sticking problems.
More research is warranted into the phenomenon of sticking and picking. The Natoli
Institute in partnership with Natoli Scientific
will continue their research and dedication to
furthering the field of pharmaceutical science